Michael was born on July 5, 1948 in Rockford, Illinois and spent his early life in Winnebago, Illinois on a small farm. He was greatly inspired by his father, Eugene, a microbiologist who helped develop yellow fever vaccine.

Eventually, Dr. Hyson attained a BS in Biology at the University of Miami in 1970, followed by a MS in Biology in 1973, and a Ph.D. in Biology in 1976 with specialization in neurobiology. From 1977-79 he pursued a Post Doctorate in Bioinformation Systems at CalTech. From 1980-87 he worked as a systems engineer for electrostatic levitation at Jet Propulsion Laboratories (JPL). From 1988-89 he functioned as research director at Pacific American Launch Systems. From 1990 to the present day he is the Research Director of the Sirius Institute.

Presently he is a full-time Consultant with the Resonance Project Foundation and a member of the Board of Directors.